反应详情

To a solution of 3-trifluoromethylimidazo[1,2-b][1,2,4]triazine (0.2211 g, 1.18 mmol) in acetic acid (6 ml) was added sodium acetate (0.1470 g, 1.79 mmol), then bromine (90.8 μl, 1.76 mmol). The solution was stirred at room temperature for 6 h, then partitioned between saturated aqueous NaHCO3 (100 ml) and ethyl acetate (100 ml). The aqueous layer (pH 9) was further extracted with ethyl acetate (100 ml), and the combined organic extracts were dried (Na2SO4) and evaporated in vacuo. The residue was purified by flash chromatography (silica gel, 25% EtOAc/isohexane) to afford 0.2073 g (66%) of the title compound: 1H NMR (360 MHz, CDCl3) δ 8.30 (1H, s), 8.83 (1H, s).

1. custompartitioned between saturated aqueous NaHCO3 (100 ml) and ethyl acetate (100 ml)
2. extractionThe aqueous layer (pH 9) was further extracted with ethyl acetate (100 ml)
3. dry with materialthe combined organic extracts were dried (Na2SO4)
4. customevaporated in vacuo
5. customThe residue was purified by flash chromatography (silica gel, 25% EtOAc/isohexane)