7-(2-Chloropyridin-4-yl)-3-trifluoromethylimidazo[1,2-b][1,2,4]triazine → 5-Fluoro-2-[4-(3-trifluoromethylimidazo[1,2-b][1,2,4]triazin-7-yl)pyridin-2-yl]benzonitrile

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Reaction Steps

7-(2-Chloropyridin-4-yl)-3-trifluoromethylimidazo[1,2-b][1,2,4]triazine was reacted with 5-fluoro-2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzonitrile by a similar procedure to that described in Example 1, step g, to give the title compound in 24% yield: 1H NMR (400 MHz, CD Cl3) δ 7.48 (1H, ddd, J 2.7, 7.8, 8.6), 7.57 (1H, dd, J 2.7, 8.2), 8.01 (1H, dd, J 5.3, 8.8), 8.08 (1H, dd, J 1.8, 5.3), 8.63 (1H, dd, J 1.0, 1.8), 8.82 (1H, s), 8.92 (1H, s), 8.95 (1H, dd, J 1.0, 5.3).

Provenance & Evidence