Cesium carbonate → HCID 21083626, compound

Participants

Reaction Conditions

Reaction Steps

To 5-bromo-2-pyridone (1.0 g) and 2-chloro-3-cyanopyridine (1.0 g) in dry N,N-dimethylformamide (20 ml) was added caesium carbonate (2.73 g), and the mixture heated at 75° C. under a nitrogen atmosphere for 24 h. The solvent was removed in vacuo from the mixture and the residue partitioned between ethyl acetate and water. The organic layer was evaporated and the residue purified by chromatography (silica gel, 0 to 4% MeOH/CH2Cl2) to give the title compound, crystallised from diethyl ether/isohexane: 1H NMR (400 MHz, CDCl3) δ 8.81 (1H, dd, J 2.0, 5.1), 8.17 (1H, dd, J 1.8, 7.6), 7.67 (1H, d, J 2.7), 7.56 (1H, dd, J 4.9, 7.6), 7.49 (1H, dd, J 2.5, 10.0), 6.62 (1H, d, J 9.8); MS (ES+) m/z 276 and 278 [M+H]+.

Provenance & Evidence