HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → 6-benzyloxy-3-thiophen-2-yl-1H-quinoxalin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 6-hydroxy-3-thiophen-2-yl-1H-quinoxalin-2-one | HCID 21083664 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-benzyloxy-3-thiophen-2-yl-1H-quinoxalin-2-one | HCID 21083661 | — |
Reaction Steps
The quinoxalin-2-one of the present example is prepared treating 6-hydroxy-3-thiophen-2-yl-1H-quinoxalin-2-one from Example 43 in DMF with bromomethyl benzene in the presence of K2CO3 at a temperature between 25° C. to 80° C. The resulting reaction mixture, after workup and purification, affords 6-benzyloxy-3-thiophen-2-yl-1H-quinoxalin-2-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07176208B2 |
| Source dataset | uspto-grants-2007_02 |
| ORD ID | ord-438c61ca98854798bdee52aeadc91d48 |
| Source note | uspto-grants-2007_02 |