Sodium Hydroxide → HCID 17864750, compound

HRID 347725Notes

Reaction equation

HRID 347725 reaction equation
C([O:3][C:4]([CH:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:17]=[C:16]([N+:18]([O-:20])=[O:19])[CH:15]=[CH:14][C:13]=2[O:21][CH3:22])[CH2:8][CH2:7]1)=[O:5])C.[OH-].[Na+]>CO>[CH3:22][O:21][C:13]1[CH:14]=[CH:15][C:16]([N+:18]([O-:20])=[O:19])=[CH:17][C:12]=1[N:9]1[CH2:10][CH2:11][CH:6]([C:4]([OH:5])=[O:3])[CH2:7][CH2:8]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 68570414HCID 68570414, compound

Product 1

HCID 17864750HCID 17864750, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
25 °C

Procedure

To a solution of this ester compound in methanol (10 ml) is added 2M aqueous sodium hydroxide solution (10 ml), and the mixture is stirred at 25° C. overnight. The reaction solution is concentrated, and diluted with water and ethyl acetate. The aqueous layer is acidified with conc. hydrochloric acid, and the resulting precipitates are collected by filtration to give the title compound (0.70 g).

Workup

  1. concentrationThe reaction solution is concentrated
  2. additiondiluted with water and ethyl acetate
  3. customthe resulting precipitates
  4. filtrationare collected by filtration

Sources & evidence

ORD record
ord-0279dde8b92e4ed181ff2c6419c6778a
Source dataset
uspto-grants-2007_02
Patent number
US07176199B2

Reaction notes

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