Trifluoroacetic acid → HCID 12096116, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the compound of Example 29 in methanol (10 ml) is added 2M aqueous sodium hydroxide solution (10 ml), and the mixture is stirred at 25° C. overnight. The reaction solution is neutralized with trifluoroacetic acid, purified by CHP-20 (eluent: gradient, 35% to 100% methanol/0.05% aqueous trifluoroacetic acid solution) to give the title compound.

Provenance & Evidence