4-[2-(2,2,2-Trifluoroethyl)guanidino]-2-(4-aminobutylthio)pyrimidine → HCID 178503915, compound

HRID 34777Notes

Reaction equation

HRID 34777 reaction equation
[F:1][C:2]([F:21])([F:20])[CH2:3][N:4]=[C:5]([NH2:19])[NH:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]([S:13][CH2:14][CH2:15][CH2:16][CH2:17][NH2:18])[N:8]=1>C(#N)C>[F:21][C:2]([F:1])([F:20])[CH2:3][N:4]=[C:5]([NH2:19])[NH:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]([S:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][C:9](=[N:8][C:7]#[N:6])[S:13][CH3:14])[N:8]=1

Participants

3

Reactant 1

HCID 212987464-[2-(2,2,2-Trifluoroethyl)guanidino]-2-(4-aminobutylthio)pyrimidine

Product 1

HCID 178503915HCID 178503915, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Dimethyl(cyanoimido)dithiocarbonate (0.08 g.) was added to a solution of 4-[2-(2,2,2-trifluoroethyl)guanidino]-2-(4-aminobutylthio)pyrimidine (0.17 g.) in acetonitrile (2 ml.) and the solution left at room temperature for 18 hours and then evaporated to dryness to give 4-[2-(2,2,2-trifluoroethyl)guanidino]-2-[4-(3-cyano-2-methylisothioureido)butylthio]pyrimidine, characterised as the hydrogen maleate m.p. 181°-183°.

Workup

  1. customevaporated to dryness

Sources & evidence

ORD record
ord-51ac8a13115e4a39a8b42d3e99ed9f07
Source dataset
uspto-grants-1988_08
Patent number
US04762932

Reaction notes

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