HRID347773

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1049

Pyridine

C5H5N

HCID1112

Succinic semialdehyde

C4H6O3

结构：Cc1c(-c2ccccc2Cl)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F

HCID21027675

未命名化合物

PRODUCTS

生成物

结构：Cc1c(-c2ccccc2Cl)c(=O)n(C[C@H](NCCCC(=O)O)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F

HCID21027673

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

To compound 2b (0.03 mmol) in 1 mL MeOH, succinic semialdehyde (0.03 mmol) was added followed by addition of 8 M BH3: Pyridine (0.03 mmol). After overnight shaking, the compound 2-1 was purified by prep. LC-MS. MS (CI) m/z 618.2 (MH+) tR=1.005 (method 1)

WORKUP

后处理

additionfollowed by addition of 8 M
customthe compound 2-1 was purified by prep

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d96c7ed306d749b7b3d0a3bba0aa05e7
来源数据集: uspto-grants-2007_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07176211B2
来源说明: uspto-grants-2007_02

反应 SMILES

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:9](=[O:37])[N:10]([CH2:28][C@H:29]([NH2:36])[C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:11](=[O:27])[N:12]([CH2:15][C:16]2[C:21]([C:22]([F:25])([F:24])[F:23])=[CH:20][CH:19]=[CH:18][C:17]=2[F:26])[C:13]=1[CH3:14].[CH2:38]([CH:43]=O)[CH2:39][C:40]([OH:42])=[O:41].N1C=CC=CC=1>CO>[OH:42][C:40]([CH2:39][CH2:38][CH2:43][NH:36][C@H:29]([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[CH2:28][N:10]1[C:9](=[O:37])[C:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])=[C:13]([CH3:14])[N:12]([CH2:15][C:16]2[C:21]([C:22]([F:25])([F:23])[F:24])=[CH:20][CH:19]=[CH:18][C:17]=2[F:26])[C:11]1=[O:27])=[O:41]