HCID 15697757, compound → HCID 11183347, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl (1S, 3S, 4R)-2-[(R)-1-phenylethyl]-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylate (3.01 g, 11.1 mmol) in ethyl acetate (22 ml) was added 20 wt % Pd(OH)2 (3.89 g) and the mixture was stirred under a hydrogen atmosphere at 45° C. for 60 hours. After a filtration through Celite, the solvent was concentrated. The residue was purified by silica gel column chromatography (1%–2.5% methanol/chloroform), to give ethyl (1R, 3S, 4S)-2-azabicyclo[2.2.1]heptane-3-carboxylate (0.724 g, 39%).

Provenance & Evidence