Hydrochloric Acid → HCID 21084197, compound

Participants

Reaction Steps

To a solution of ethyl 2-(4-methoxybenzoyl)-2-azabicyclo[2.2.1]heptane-3-carboxylate (239 mg, 0.787 mmol) in tetrahydrofuran (5 ml)-methanol (4 ml) was added 1N sodium hydroxide (5 ml), and the mixture was stirred at room temperature for 3 hours. The reaction mixture was acidified with 1N hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over magnesium sulfate. The solvent was evaporated, to give 2-(4-methoxybenzoyl)-2-azabicyclo[2.2.1]heptane-3-carboxylic acid.

Provenance & Evidence