Water → HCID 9858633, compound

Participants

Reaction Steps

A mixture of cyanuric chloride (28 mg, 0.15 mmol) and the compound of Example 75 (52 mg, 0.15 mmol) in DMF (1.5 mL) was heated at 110° for 18 h. Two further portions of cyanuric chloride (14 mg, 0.075 mmol) were added and heating continued for a further 26 h. Water was added and the precipitate filtered off, washed with water and dried. The crude product was purified by column chromatography on silica (1% THF in DCM) to give the title compound as a white solid (35 mg, 71%). δH (DMSO-d6) 7.78 (1H, d, J 9.6 Hz), 7.71–7.67 (1H, m), 7.66–7.64 (1H, m), 7.64–7.59 (7H, m), 7.59–7.58 (1H, m), 6.67 (1H, d, J 9.6 Hz). LCMS (ES+) RT 3.65 minutes, 329 (M+H)+.

Provenance & Evidence