Trifluoroacetic acid → HCID 21083983, compound

Participants

Reaction Steps

Trifluoroacetic acid (2 mL) was added to a solution of the compound of Example 80 (170 mg, 0.406 mmol) in DCM (2 mL) and the reaction mixture stirred for 2 h at r.t. The mixture was added to saturated NaHCO3(aq) (20 mL) and the product extracted with DCM (2×20 mL). The combined organic fractions were dried (MgSO4), filtered and concentrated in vacuo. The crude product was purified by flash column chromatography on silica (EtOAc), followed by radial chromatography (20% EtOH in DCM) to give the title compound as a buff solid (30 mg, 23%). δH (CDCl3) 7.8–7.3 (13H, m), 6.58 (1H, d, J 9 Hz). m/z (ES+) 319 (M+H)+.

Provenance & Evidence