Trifluoroacetic acid → HCID 21084085, compound

Participants

Reaction Steps

Trifluoroacetic acid (2.5 mL) was added to a solution of the compound of Example 82 (105 mg, 0.212 mmol) in DCM (2.5 mL) and the reaction mixture stirred for 2 h at r.t. The mixture was added to saturated NaHCO3 solution (20 mL) and the product extracted with DCM (2×20 mL). The combined organic fractions were dried (MgSO4), filtered and concentrated in vacuo. The crude product was purified by radial chromatography on silica (EtOAc) to give the title compound (62 mg, 74%). δH (CDCl3) 7.6–7.25 (11H, m), 6.58 (1H, d, J 9 Hz), 6.31 (1H, br s), 2.53 (3H, s). m/z (ES+) 397 (M+H)+.

Provenance & Evidence