Hydrochloric Acid → HCID 9814932, compound

Participants

Reaction Steps

2M HCl(aq) (10 mL) was added to a solution of the compound of Example 59 (300 mg, 0.864 mmol) in dioxane (30 mL) and the mixture heated at reflux for 16 h. The cooled reaction mixture was poured into 10% NaOH(aq) (50 mL) and extracted with DCM (2×50 mL) The combined organic fractions were dried (Na2SO4), filtered and concentrated in vacuo to give the title compound as a white solid in quantitative yield. δH (CDCl3) 7.83 (1H, d, J 9 Hz), 7.7–7.35 (10 H, m), 6.80 (1H, s), 6.67 (1H, d, J 9 Hz). m/z (ES+) 304 (M+H)+.

Provenance & Evidence