Triethylamine → HCID 21084040, compound

Participants

Reaction Steps

The compound of Example 118 (104 mg, 0.26 mmol) was dissolved in DCM (5 mL) and triethylamine (73 μL) followed by methanesulphonylchloride (40 μL, 0.28 mmol) added. The reaction was allowed to stir at ambient temperature for 18 hours. The reaction was diluted with brine and extracted with DCM (×3). The organic phases were washed with saturated NaHCO3 solution and dried (MgSO4). The reaction was filtered and the solvents removed in vacuo to give the title product as a white solid (120 mg). δH (CDCl3) 7.45–7.30 (3H, m), 7.27–7.10 (3H, m), 6.43 (1H, d, J 9.4 Hz), 4.12 (2H, q, J 7.1 Hz), 4.02 (2H, d, J 7.2 Hz), 3.75 (2H, m), 2.70 (3H, s), 2.61 (2H, m), 2.20 (1H, m), 1.82 (2H, m), 1.55 (2H, m), 1.12 (3H, t, J 7.1 Hz). LCMS (ES+) RT 3.55 minutes, 475 (M+H)+

Provenance & Evidence