HCID 21084046, compound → HCID 21084042, compound

Participants

Reaction Steps

A mixture of the compound of Example 120 (455 mg, 1.08 mmol) and palladium on charcoal (10% Pd wt/wt, 90 mg) in EtOH (20 mL) was stirred under an atmosphere of hydrogen (balloon) for 45 h. The catalyst was filtered off and the filtrate concentrated in vacuo. Purification by column chromatography on silica (3% to 5% THF in DCM) gave the title compound as a pale yellow solid (257 mg, 61%). δH (DMSO-d6) 7.59–7.52 (3H, m), 7.48–7.44 (3H, m), 7.33–7.28 (1H, m), 7.16 (1H, dd, J 1.5, 7.8 Hz), 6.98 (1H, dd, J 1.2, 8.2 Hz), 6.77–6.73 (1H, m), 6.59 (1H, d, J 9.6 Hz), 5.33 (2H, br s), 4.12 (2H, q, J 7.1 Hz), 1.12 (3H, t, J 7.1 Hz). ). LCMS (ES+) RT 3.581 minutes, 391.0 (M+H)+.

Provenance & Evidence