Ammonia → HCID 21083995, compound

Participants

Reaction Steps

A mixture of the compound of Example 126 (125 mg, 0.328 mmol) and 1,1′-carbonyldiimidazole (80 mg, 0.49 mmol) in DMF (3 mL) was stirred at r.t. for 90 min. Concentrated ammonia solution (0.5 mL) was added and the mixture stirred for 1 h. Volatiles were removed in vacuo. The residue was treated with 2M HCl(aq) and the resulting solid filtered off and dried. Purification by column chromatography on silica (3% MeOH in DCM) gave the title compound as a pale brown solid (105 mg, 84%). δH (DMSO-d6) 7.91–7.89 (1H, m), 7.83–7.80 (1H, m), 7.76–7.69 (2H, m), 7.66–7.59 (3H, m), 7.56–7.53 (2H, m), 7.51 (1H, d, J 9.7 Hz), 6.62 (1H, d, J 9.6 Hz), 6.2 (2H, br s). LCMS (ES+) RT 3.120 minutes, 380.8 (M+H)+.

Provenance & Evidence