反应详情

A mixture of 4-[2-(2,2,2-trifluoroethyl)guanidino]-2-(2-aminoethylthio)pyrimidine (0.25 g.), acetonitrile (5 ml.) and dimethyl(cyanoimido)dithiocarbonate (0.12 g.) was left at room temperature for 24 hours and then evaporated to dryness. The residue was dissolved in a 33% w/v solution of methylamine in ethanol, and the solution left at room temperature for 24 hours and then evaporated to dryness. The residue was recrystallised from ethanol to give 4-[2-(2,2,2-trifluoroethyl)guanidino]-2-[2-(2-cyano-3-methylguanidino)ethylthio]pyrimidine, m.p. 218°-221°.

1. customevaporated to dryness
2. dissolutionThe residue was dissolved in a 33% w/v solution of methylamine in ethanol
3. waitthe solution left at room temperature for 24 hours
4. customevaporated to dryness
5. customThe residue was recrystallised from ethanol