Acetic Anhydride → 1-Acetyl-5-hexanoyl-3-(ethoxy-phenyl-methylidene)-2-indolinone

HRID 347964Notes

Reaction equation

HRID 347964 reaction equation
[C:1]([C:8]1[CH:9]=[C:10]2[C:14](=[CH:15][CH:16]=1)[NH:13][C:12](=[O:17])[CH2:11]2)(=[O:7])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[C:18](OC(=O)C)(=[O:20])[CH3:19].[CH3:25][CH2:26][O:27][C:28](OCC)(OCC)[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>C(Cl)Cl.CO>[C:18]([N:13]1[C:14]2[C:10](=[CH:9][C:8]([C:1](=[O:7])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6])=[CH:16][CH:15]=2)[C:11](=[C:28]([O:27][CH2:26][CH3:25])[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[C:12]1=[O:17])(=[O:20])[CH3:19]

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 74268Benzene, (triethoxymethyl)-HCID 210846455-Hexanoyl-2-indolinone

Product 1

HCID 689930081-Acetyl-5-hexanoyl-3-(ethoxy-phenyl-methylidene)-2-indolinone

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Prepared from 5-hexanoyl-2-indolinone, acetic anhydride and triethyl orthobenzoate Rf=0.72 (methylene chloride/methanol 30:1)

Sources & evidence

ORD record
ord-288222444a0b48e9917ce003a064b787
Source dataset
uspto-grants-2007_02
Patent number
US07176231B2

Reaction notes

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