3-(3-AMino-1H-pyrazol-1-yl)propanenitrile → HCID 54298987, compound

HRID 34801Notes

Reaction equation

HRID 34801 reaction equation
[F:1][C:2]([F:8])([F:7])[CH2:3][N:4]=[C:5]=[S:6].[NH2:9][C:10]1[CH:14]=[CH:13][N:12]([CH2:15][CH2:16][C:17]#[N:18])[N:11]=1>C(#N)C>[F:1][C:2]([F:8])([F:7])[CH2:3][NH:4][C:5](=[S:6])[NH:9][C:10]1[CH:14]=[CH:13][N:12]([CH2:15][CH2:16][C:17]#[N:18])[N:11]=1

Participants

4

Reactant 2

HCID 122459333-(3-AMino-1H-pyrazol-1-yl)propanenitrileHCID 138837771,1,1-Trifluoro-2-isothiocyanatoethane

Product 1

HCID 54298987HCID 54298987, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

2,2,2-Trifluoroethylisothiocyanate (3.4 g.) was added to a solution of 3-amino-1-(2-cyanoethyl)pyrazole (2.72 g.) in acetonitrile (10 ml.) and the solution left at room temperature for 18 hours. The mixture was evaporated to dryness and the residue recrystallised from ethanol to give 3-[3-(2,2,2-trifluoroethyl)thioureido]-1-(2-cyanoethyl)pyrazole, m.p. 164°-165°.

Workup

  1. customThe mixture was evaporated to dryness
  2. customthe residue recrystallised from ethanol

Sources & evidence

ORD record
ord-6352f2f7aca24241984058390f8d45ed
Source dataset
uspto-grants-1988_08
Patent number
US04762932

Reaction notes

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