Acetyl chloride → HCID 10028110, compound

Participants

Reaction Steps

To a mixture of 3-(4-chlorophenyl)-2-(2-chlorophenyl)-5-methyl-7-piperazin-1-yl-pyrazolo[1,5-a]pyrimidine, hydrochloride salt (6A-3; 25 mg, 0.049 mmol), Argonaut™ PS-DIEA (63 mg, 0.24 mmol) and diisopropylethylamine (0.020 ml, 0.11 mmol) in methylene chloride (1 ml), was added acetyl chloride (0.005 ml, 0.074 mmol). After stirring 20 minutes, the reaction was filtered, concentrated and then purified on a Biotage™ Flash 12S column using 0–50% ethyl acetate in hexanes as eluant to afford, after trituration from hexanes/methylene chloride, 7A-1 (19 mg, 79%) as a solid: +ESI MS (M+1) 480.3; 1H NMR (400 MHz, CD3OD) δ 7.49–7.34 (m, 6H), 7.23 (d, J=8.7 Hz, 2H), 6.14 (s, 1H), 3.84–3.78 (m, 4H), 3.71–3.61 (m, 4H), 2.57 (s, 3H), 2.10 (s, 3H).

Provenance & Evidence