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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 348048Generated: October 30, 2026

Dabco → 1-[3-(4-{1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxoazetidin-2-yl}phenoxymethyl)benzyl]-4-aza-1-azoniabicyclo[2.2.2]octane bromide

https://huagongshe.com/reaction/348048

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDabcoHCID 9237—
Reactant4-[4-(3-Bromomethylbenzyloxy)phenyl]-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]azetidin-2-oneHCID 21083184—
SolventTolueneHCID 1140—
Product1-[3-(4-{1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxoazetidin-2-yl}phenoxymethyl)benzyl]-4-aza-1-azoniabicyclo[2.2.2]octane bromideHCID 21083147—

Reaction Steps

Compound (18) and DABCO were dissolved in toluene and reacted analogously to Example IV, giving the product (19) as a colorless solid of molecular weight 704.66 (C38H40BrF2N3O3); MS (ESI): 624.30 (MH+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07176194B2
Source datasetuspto-grants-2007_02
ORD IDord-41a3a046269641aeab5d4122b4644e75
Source noteuspto-grants-2007_02