HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 1-[4-(4-Bromomethylbenzyloxy)-phenyl]-3-[3-(4-fluorophenyl)-3-hydroxypropyl]4-(4-methoxyphenyl)-azetidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1,4-Bis(bromomethyl)benzene | HCID 69335 | — |
| Reactant | 3-[3-(4-Fluorophenyl)-3-hydroxypropyl]-1-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-azetidin-2-one | HCID 21083179 | — |
| Product | 1-[4-(4-Bromomethylbenzyloxy)-phenyl]-3-[3-(4-fluorophenyl)-3-hydroxypropyl]4-(4-methoxyphenyl)-azetidin-2-one | HCID 21083167 | — |
Reaction Steps
3-[3-(4-Fluorophenyl)-3-hydroxypropyl]-1-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-azetidin-2-one was reacted with 1,4-bisbromomethylbenzene and potassium carbonate analogously to Example IV, giving a colorless solid (25) of molecular weight 604.52 (C33H31BrFNO4); MS (ESI): 605.2 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07176194B2 |
| Source dataset | uspto-grants-2007_02 |
| ORD ID | ord-5477cd4cc20a4dfaa9bba38390e4f108 |
| Source note | uspto-grants-2007_02 |