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HRID 348054作成日：2026年10月25日

Dabco → 1-[4-(4-{3-[1-(4-Fluorophenyl)-2-(4-methoxyphenyl)-4-oxoazetidin-3-yl]-1-hydroxypropyl}-phenoxymethyl)-benzyl]-4-aza-1-azoniabicyclo[2.2.2]octane bromide

https://huagongshe.com/reaction/348054

反応式

関与物質

役割名称HCID仕込み量
反応物DabcoHCID 9237—
反応物3-{3-[4-(4-Bromomethylbenzyloxy)-phenyl]-3-hydroxypropyl}-1-(4-fluorophenyl)4-(4-methoxyphenyl)-azetidin-2-oneHCID 21083178—
溶媒TolueneHCID 1140—
生成物1-[4-(4-{3-[1-(4-Fluorophenyl)-2-(4-methoxyphenyl)-4-oxoazetidin-3-yl]-1-hydroxypropyl}-phenoxymethyl)-benzyl]-4-aza-1-azoniabicyclo[2.2.2]octane bromideHCID 21083161—

反応手順

Compound (29) and DABCO were dissolved in toluene and reacted analogously to Example IV, giving the product (30) as a colorless solid of molecular weight 716.70 (C39H43BrFN3O4); MS (ESI): 636.3 (MH+).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07176194B2
出典データセットuspto-grants-2007_02
ORD IDord-3575a41fc7b34528bd2636af581dcb35
出典メモuspto-grants-2007_02