反应详情

To a solution of 2-[3-(2,2,2-trifluoroethyl)thioureido]-6-chloropyrazine (0.7 g.) in alcoholic ammonia (35 ml.) was added red mercuric oxide (0.65 g.) with stirring at room temperature. After stirring overnight, the black mixture was filtered and the black solid washed with alcohol. The resulting yellow filtrate was evaporated to give a yellow solid (0.7 g.). Recrystallisation from hot toluene diluted with petroleum ether (b.p. 60°-80°) yielded colourless needles (0.5 g.) of 2-[2-(2,2,2-trifluoroethyl)guanidino]-6-chloropyrazine m.p. 139°-140°.

1. stirringAfter stirring overnight
2. filtrationthe black mixture was filtered
3. washthe black solid washed with alcohol
4. customThe resulting yellow filtrate was evaporated
5. customto give a yellow solid (0.7 g.)
6. customRecrystallisation from hot toluene
7. additiondiluted with petroleum ether (b.p. 60°-80°)