HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl isothiocyanate → 2-[2-(2,2,2-Trifluoroethyl)guanidino]-6-[3-(3-methylthioureido)propylthio]pyrazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl isothiocyanate | HCID 11167 | — |
| Reactant | 2-[2-(2,2,2-Trifluoroethyl)guanidino]-6-(3-aminopropylthio)pyrazine | HCID 21298819 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-[2-(2,2,2-Trifluoroethyl)guanidino]-6-[3-(3-methylthioureido)propylthio]pyrazine | HCID 21298784 | — |
Reaction Steps
A solution of 2-[2-(2,2,2-trifluoroethyl)guanidino]-6-(3-aminopropylthio)pyrazine in warm acetonitrile (15 ml.) was allowed to cool to room temperature. A solution of methylisothiocyanate (0.15 g.) in acetonitrile (1 ml.) was added and the mixture stirred overnight. Evaporation to dryness gave a yellow solid which was recrystallised from a small volume of ethyl acetate to yield 2-[2-(2,2,2-trifluoroethyl)guanidino]-6-[3-(3-methylthioureido)propylthio]pyrazine (0.32 g.), m.p. 165°-167°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04762932 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-f8bd328d315843af98919105ae7a1fdb |
| Source note | uspto-grants-1988_08 |