huagongshe.com
HRID348243

反应详情

EQUATION

反应方程式

HRID 348243 的结构方程式

REACTANTS

反应物

2
结构：CC(C=O)=P(c1ccccc1)(c1ccccc1)c1ccccc1
HCID4280987

2-(Triphenylphosphoranylidene)propionaldehyde

C21H19OP

结构：O=Cc1csc(COC(=O)OCC(Cl)(Cl)Cl)n1
HCID10495826

未命名化合物

PRODUCTS

生成物

1
结构：CC(C=O)=Cc1csc(COC(=O)OCC(Cl)(Cl)Cl)n1
HCID85274831

未命名化合物

收率 90.5%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：c1ccccc1
溶剂HCID241

Benzene

C6H6

PROCEDURE

实验过程

A mixture of 2-(2,2,2-trichloroethoxycarbonyloxymethyl)thiazole-4-carboxaldehyde (21.0 g) and 2-(triphenylphosphoranylidene)propionaldehyde (20.6 g) in 300 mL of benzene is heated at reflux for 3 hours, then cooled to ambient temperature and concentrated. Purification by flash column chromatography on SiO2 (hexanes/ethyl acetate, 4:1) yields the product as a clear oil (21.0 g).

WORKUP

后处理

  1. temperatureis heated
  2. temperatureat reflux for 3 hours
  3. concentrationconcentrated
  4. customPurification by flash column chromatography on SiO2 (hexanes/ethyl acetate, 4:1)