反应详情

The above thiourea (1.32 g.) was stirred in 1.6N alcoholic ammonia (50 ml.) with mercuric oxide (3.4 g.) for 17 hours at 20°. The resulting mixture was clarified on the centrifuge and the supernatant was evaporated in vacuo to a syrup which was further dried at 70°/0.1 m.m. to give 1-(3-hydroxymethylphenyl)-3-(2,2,2-trifluoroethyl)guanidine. The n.m.r. spectrum in d6 dimethylsulphoxide using tetramethyl silane as internal standard (δ=0) had the following resonances (δ): 6.9 (4H, multiplet); 4.4 (2H, singlet); 3.9 (2H, quartet).

1. customthe supernatant was evaporated in vacuo to a syrup which
2. customwas further dried at 70°/0.1 m