反应详情

温度

55 °C

3-{4-[2-(2-Biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-phenyl}-2-methyl-2-phenoxypropionic acid ethyl ester (3.6 mmol) in MeOH (7 mL) was treated with 2N NaOH (7 mL) and warmed to 55° C. After 18 h, the mixture was concentrated under reduced pressure and then acidified with 5N HCl to pH=1. The solution was extracted with EtOAc and then the organic phases dried (Na2SO4), filtered and concentrated to a white solid (7%). MS [EI+] 534 (M+H)+, 566 (M+Na)+, [EI−] 532 (M−H)+; HPLC: T=3.29 min, purity 99%.

1. concentrationthe mixture was concentrated under reduced pressure
2. extractionThe solution was extracted with EtOAc
3. dry with materialthe organic phases dried (Na2SO4)
4. filtrationfiltered
5. concentrationconcentrated to a white solid (7%)
6. customT=3.29 min, purity 99%