Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Butanoic acid, 2-bromo-, ethyl ester | HCID 79039 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ethyl 2-phenoxybutanoate | HCID 15380339 | — |
Reaction Steps
Phenol (28.5 g, 0.30 mol), Cs2CO3 (197.0 g, 0.61 mol), and ethyl 2-bromobutyrate (0.30 mol) were combined in anhydrous DMF (1000 mL) and stirred at 90° C. under an atmosphere of nitrogen. After 16 h, the DMF was removed in vacuo. The residue was dissolved in ethyl acetate (300 mL) and washed twice with water and once with brine. The organic layer was dried over Na2SO4 and concentrated in vacuo to produce an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07176224B2 |
|---|
| Source dataset | uspto-grants-2007_02 |
|---|
| ORD ID | ord-0483c7443ac2405e8c6aea90270c2ae5 |
|---|
| Source note | uspto-grants-2007_02 |
|---|
