HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-Difluorophenoxy-3-(4-benzyloxyphenyl)-2-methyl-propionic acid ethyl ester → 2-(3,4-Difluorophenoxy)-3-(4-hydroxyphenyl)-2-methyl-propionic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-Difluorophenoxy-3-(4-benzyloxyphenyl)-2-methyl-propionic acid ethyl ester | HCID 69353847 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-(3,4-Difluorophenoxy)-3-(4-hydroxyphenyl)-2-methyl-propionic acid ethyl ester | HCID 69319839 | — |
Reaction Steps
2-(3,4-Difluorophenoxy-3-(4-benzyloxyphenyl)-2-methyl-propionic acid ethyl ester (2.1 mmol) was dissolved in ethyl acetate (30 mL) and treated with 5% palladium on carbon (300 mg), and stirred under an atmosphere of hydrogen for 20 h. The suspension was filtered through celite and concentrated in vacuo to an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07176224B2 |
| Source dataset | uspto-grants-2007_02 |
| ORD ID | ord-28e7ac0300e04b638acd41ab08e6faa1 |
| Source note | uspto-grants-2007_02 |