HCID 20741403, compound → HCID 12990810, compound

Participants

Reaction Conditions

Reaction Steps

To an ethanol (20 ml) solution of 3-(R)-[1-tert-butoxycarbonylamino-1-phenylmethyl]-1-[1-(R)-phenylethyl]pyrrolidine [F1] (495 mg, 1.30 mmol) was added a 10% palladium-carbon catalyst (water content 53.8%, 500 mg) and catalytic hydrogenation was carried out under heating at an outer temperature of 50° C. at normal pressure for 4 hours. The reaction solution was filtered and the solvent was removed under reduced pressure to obtain a crude product of the title compound (359 mg, quantitative) as colorless crystals.

Provenance & Evidence