HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Hydroxy-thiophene-2-carboxylic acid methyl ester → 3-{2-[5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetoxy}-thiophene-2-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Hydroxy-thiophene-2-carboxylic acid methyl ester | HCID 581127 | — |
| Reactant | [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid | HCID 21087356 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 3-{2-[5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetoxy}-thiophene-2-carboxylic acid methyl ester | HCID 69524131 | 44% |
Reaction Steps
The titled compound was prepared from [5-(4-fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid using 3-hydroxy-thiophene-2-carboxylic acid methyl ester (20 mg, 0.13 mmol) as the source alcohol. Chromatography (5% methanol/dichloromethane) through SiO2 yielded 32 mg (44%) of the titled compound. ESI-MS m/z 432 (MH+), 430 (M−H−).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07176310B1 |
| Source dataset | uspto-grants-2007_02 |
| ORD ID | ord-4b739139ebd24e4b9e8c3cbe4a85b0f6 |
| Source note | uspto-grants-2007_02 |