HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Dimethylphenol → [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid 2,4-dimethyl-phenyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Dimethylphenol | HCID 7771 | — |
| Reactant | [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid | HCID 21087356 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid 2,4-dimethyl-phenyl ester | HCID 69522908 | 71% |
Reaction Steps
The titled compound was prepared from [5-(4-fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid using 2,4-dimethylphenol (16 mg, 0.13 mmol) as the source alcohol. Chromatography (5% methanol/dichloromethane) through SiO2 yielded 48 mg (71%) of the titled compound as a white solid. ESI-MS m/z 396 (MH+), 394 (M−H−).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07176310B1 |
| Source dataset | uspto-grants-2007_02 |
| ORD ID | ord-82eea71ddb4648a9affc0a63cbf12e45 |
| Source note | uspto-grants-2007_02 |