HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid cyclobutylmethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Cyclobutylcarbinol | HCID 78130 | — |
| Reactant | [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid | HCID 21087356 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid cyclobutylmethyl ester | HCID 69522798 | 92% |
Reaction Steps
The titled compound was prepared from [5-(4-fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid using cyclobutanemethanol (32 μL, 0.34 mmol) as the coupling partner. Chromatography (1:1 methanol:dichloromethane) through SiO2 yielded 56 mg (92%) of the titled compound. ESI-MS m/z 360 (MH+), 358 (M−H−).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07176310B1 |
| Source dataset | uspto-grants-2007_02 |
| ORD ID | ord-b6a206b14c174480a9062e2b98f133d9 |
| Source note | uspto-grants-2007_02 |