HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-Bromophenyl)-4-hydroxypiperidine → 2-{2-[4-(4-Bromophenyl)-4-hydroxy-piperidin-1-yl]-2-oxo-ethoxy}-pyrimidine-5-carboxylic acid (4-fluorophenyl)amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-Bromophenyl)-4-hydroxypiperidine | HCID 93911 | — |
| Reactant | [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid | HCID 21087356 | — |
| Product | 2-{2-[4-(4-Bromophenyl)-4-hydroxy-piperidin-1-yl]-2-oxo-ethoxy}-pyrimidine-5-carboxylic acid (4-fluorophenyl)amide | HCID 86760386 | 84% |
Reaction Steps
The titled compound was prepared from [5-(4-fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid using 4-(4-bromophenyl)-piperidin-4-ol (56 mg, 0.22 mmol) as the coupling partner. Concentration (no chromatography) yielded 76 mg (84%) of the titled compound. ESI-MS m/z 530, 532 (MH+), 527, 529 (M−H−).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07176310B1 |
| Source dataset | uspto-grants-2007_02 |
| ORD ID | ord-eec8ff0fa6ee4dda9a96b46d4f5577c6 |
| Source note | uspto-grants-2007_02 |