3-(Dimethylamino)phenol → HCID 69523488, compound

HRID 348467Notes

Reaction equation

HRID 348467 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[CH:12]=[N:13][C:14]([O:17][CH2:18][C:19]([OH:21])=[O:20])=[N:15][CH:16]=2)=[O:10])=[CH:4][CH:3]=1.[CH3:22][N:23]([CH3:31])[C:24]1[CH:25]=[C:26](O)[CH:27]=[CH:28][CH:29]=1>>[CH3:22][N:23]([CH3:31])[C:24]1[CH:29]=[C:28]([O:20][C:19](=[O:21])[CH2:18][O:17][C:14]2[N:13]=[CH:12][C:11]([C:9](=[O:10])[NH:8][C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=3)=[CH:16][N:15]=2)[CH:27]=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 74213-(Dimethylamino)phenolHCID 21087356[5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid

Product 1

HCID 69523488HCID 69523488, compoundYield 76%

Procedure

The titled compound was prepared from [5-(4-fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid using 3-dimethylaminophenol (21 mg, 0.15 mmol) as the coupling partner. Concentration (no chromatography) yielded 53 mg (76%) of the titled compound as a pink-purple solid. ESI-MS m/z 411 (MH+), 409 (M−H−).

Workup

  1. concentrationConcentration (no chromatography)

Sources & evidence

ORD record
ord-b1b86699bced43568db0731186eb1285
Source dataset
uspto-grants-2007_02
Patent number
US07176310B1

Reaction notes

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