HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,3-Dimethyl-1-butanol → [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid 3,3-dimethyl-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,3-Dimethyl-1-butanol | HCID 12233 | — |
| Reactant | [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid | HCID 21087356 | — |
| Product | [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid 3,3-dimethyl-butyl ester | HCID 69523345 | 85% |
Reaction Steps
The titled compound was prepared from [5-(4-fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid using 3,3-dimethylbutanol (26 mg, 0.26 mmol) as the coupling partner. Concentration (no chromatography) yielded 54 mg (85%) of the titled compound. ESI-MS m/z 376 (MH+), 374 (M−H−).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07176310B1 |
| Source dataset | uspto-grants-2007_02 |
| ORD ID | ord-e17d57388c55403aa2bed5fa9b19099d |
| Source note | uspto-grants-2007_02 |