HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid 2-cyclohexyloxy-ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 2-(Cyclohexyloxy)ethanol | HCID 224775 | — |
| Reactant | [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid | HCID 21087356 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid 2-cyclohexyloxy-ethyl ester | HCID 69523264 | 51% |
Reaction Steps
The titled compound was prepared from [5-(4-fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid using 2-cyclohexyloxy-ethanol (37 mg, 0.26 mmol) as the coupling partner. Chromatography (1:1 ethyl acetate:dichloromethane) through SiO2 yielded 36 mg (51%) of the titled compound. ESI-MS m/z 418 (MH30 ), 416 (M−H−).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07176310B1 |
| Source dataset | uspto-grants-2007_02 |
| ORD ID | ord-00afb08231c04ebfbbf49e3c84463202 |
| Source note | uspto-grants-2007_02 |