Benzylamine → HCID 86760388, compound

HRID 348476Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[CH:12]=[N:13][C:14]([O:17][CH2:18][C:19]([OH:21])=O)=[N:15][CH:16]=2)=[O:10])=[CH:4][CH:3]=1.[CH2:22]([NH2:29])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]([C:11]2[CH:16]=[N:15][C:14]([O:17][CH2:18][C:19](=[O:21])[NH:29][CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[N:13][CH:12]=2)=[O:10])=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 7504Benzylamine

HCID 21087356[5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid

Product 1

HCID 86760388HCID 86760388, compoundYield 90%

Procedure

The titled compound was prepared from [5-(4-fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid using benzylamine (20 μL, 0.21 mmol) as the coupling partner. Concentration (no chromatography) yielded 58 mg (90%) of the titled compound. ESI-MS m/z 381 (MH+), 379 (M−H−).

Workup

concentrationConcentration (no chromatography)

Sources & evidence

ORD record: ord-811bd6f6ff454128a625c244fddf3501
Source dataset: uspto-grants-2007_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07176310B1

Reaction notes

Loading…