HuagongsheHuagongshe Chemistry Print Report · For research reference only
Exo-2-bornanamine → 2-(Bicyclo[2.2.1]hept-2-ylcarbamoylmethoxy)pyrimidine-5-carboxylic acid (4-fluorophenyl)amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Exo-2-bornanamine | HCID 98480 | — |
| Reactant | [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid | HCID 21087356 | — |
| Product | 2-(Bicyclo[2.2.1]hept-2-ylcarbamoylmethoxy)pyrimidine-5-carboxylic acid (4-fluorophenyl)amide | HCID 86760393 | 71% |
Reaction Steps
The titled compound was prepared from [5-(4-fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid using 2-aminonorbornane (21 μL, 0.18 mmol) as the coupling partner. Concentration (no chromatography) yielded 38 mg (71%) of the titled compound. ESI-MS m/z 385 (MH+), 383 (M−H−).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07176310B1 |
| Source dataset | uspto-grants-2007_02 |
| ORD ID | ord-97e94e58c2894e498fbf331a634b5b11 |
| Source note | uspto-grants-2007_02 |