Dimethylformamide → HCID 86760399, compound

Participants

Reaction Steps

A solution of 2-carbamoylmethylsulfinyl-4-methylpyrimidine-5-carboxylic acid (4-fluorophenyl)amide (as prepared above, 42 mg, 0.12 mmol) and m-CPBA (47 mg, 0.27 mmol) in 2 mL of 1:1 dichloromethane:DMF was stirred at ambient temperature for 3 days. The solution was diluted with 40 mL of 1:1 ethyl acetate:hexane and sequentially washed with 2×10 mL 5% NaHCO3(aq), 10 mL 0.1 M HCl(aq) and 10 mL brine. The organic layer was dried using Na2SO4 and concentrated to a white solid which was triturated with 10 mL of 1:1 dichloromethane:hexane, yielding 8 mg (19%) of the titled compound as a white solid.

Provenance & Evidence