Dimethylformamide → HCID 86760400, compound

Participants

Reaction Steps

A solution of sodium 5-(4-fluorophenylcarbamoyl)pyrimidine-2-sulfinate (76 mg, 0.24 mmol) in 2 mL of DMF was treated with 2-bromoacetophenone (48 mg, 0.24 mmol) and stirred at ambient temperature for 3 days. The solution was then diluted with 15 mL ethyl acetate and 5 mL hexane and sequentially washed with 2×5 mL portions of 0.1 M HCl and 5 mL of water. The organic phase was dried using Na2SO4, concentrated and the resultant oil chromatographed through SiO2 (2–5% MeOH/dichloromethane). Recrystallization in ethyl acetate/hexane yielded 26 mg (27%) of the titled compound as yellowish needles. ApcI-MS m/z 414 (MH+), 412 (M−H−).

Provenance & Evidence