HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethyl orthoformate → Methyl 1-methyl-1H-benzo[d]imidazole-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethyl orthoformate | HCID 9005 | — |
| Reactant | Methyl 3-amino-4-(methylamino)benzoate | HCID 15586064 | — |
| Product | Methyl 1-methyl-1H-benzo[d]imidazole-5-carboxylate | HCID 965319 | — |
Reaction Steps
A solution of methyl 3-amino-4-methylaminobenzoate (prepared as in DE 1990390463 A1) (2.57 g, 14 mmol) in trimethyl orthoformate (50 mL) was refluxed for 16 hours. The solvent was then removed under reduced pressure to afford 2.31 g of product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07176322B2 |
| Source dataset | uspto-grants-2007_02 |
| ORD ID | ord-32dc8e7f00a3425182a33ced2a8f8734 |
| Source note | uspto-grants-2007_02 |