Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dabco | HCID 9237 | — |
| Reactant | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| Reactant | Tetrahydro-4H-pyran-4-one | HCID 121599 | — |
| Reactant | Methyl 4-amino-3-iodobenzoate | HCID 4104649 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 21087570 | HCID 21087570 | 21.5% |
Reaction Steps
Tetrahydro-4H-pyran-4-one (1.3 g, 13 mmol), 4-amino-3-iodobenzoic acid methyl ester (3.46 g, 12.5 mmol), DABCO (4.37 g, 39 mmol), MgSO4 (2.35 g, 19.5 mmol) and Pd(OAc)2 (0.15 g, 0.00065 mol) were dissolved in DMF (18 mL) and heated under nitrogen at 105° C. for 2 days. The reaction mixture was then partitioned between ethyl acetate and water, and extracted. The crude was purified by column chromatography (98/2 DCM/MeOH) to give 0.62 g of title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07176322B2 |
|---|
| Source dataset | uspto-grants-2007_02 |
|---|
| ORD ID | ord-56e7c2500d1a42abbf674447f1cb4d83 |
|---|
| Source note | uspto-grants-2007_02 |
|---|
