反应详情

The compound (160 mg) obtained in Example 24-3 was added with 2.0 ml of a 40% methylamine/methanol solution (manufactured by Tokyo Kasei Kogyo Co., Ltd.), followed by stirring at room temperature for 40 hours. After completion of the reaction, the solvent was distilled off and the residue was subjected to extraction by the addition of a 1 mol/l sodium hydroxide aqueous solution and chloroform. The organic layer was dried with anhydrous sodium sulfate and the solvent was distilled off, thereby obtaining the subject compound (114 mg) as a colorless viscous liquid.

1. customAfter completion of the reaction
2. distillationthe solvent was distilled off
3. extractionthe residue was subjected to extraction by the addition of a 1 mol/l sodium hydroxide aqueous solution and chloroform
4. dry with materialThe organic layer was dried with anhydrous sodium sulfate
5. distillationthe solvent was distilled off