反应详情

A mixture of 13.99 g of 2-amino-4-methoxy-6-methylpyrimidine (0.1 mole), 14.8 g of 4-chlorothiophenol (0.1 mole), 9.4 g of aqueous 35% formaldehyde (0.11 mole) and 1 g of acetic acid are heated under reflux for 1 hour in 100 ml of methanol. The resultant solution is clarified by filtration, diluted with 150 ml of toluene and then the solvent is removed in a rotary evaporator. The residue crystallises after standing for some time. The melting point is 78°-82° after recrystallisation from hexane. The yield is 24 g (81% of theory).

1. temperatureare heated
2. filtrationThe resultant solution is clarified by filtration
3. additiondiluted with 150 ml of toluene
4. customthe solvent is removed in a rotary evaporator
5. customThe residue crystallises
6. customThe melting point is 78°-82° after recrystallisation from hexane