HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 348634Generated: October 30, 2026
Sodium Hydroxide → (4-Aminomethylbenzyl)-(4-dipropylaminomethylphenyl)-amine
https://huagongshe.com/reaction/348634
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 2-{4-[(4-Dipropylaminomethylphenylamino)methyl]benzyl}isoindole-1,3-dione | HCID 21084376 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (4-Aminomethylbenzyl)-(4-dipropylaminomethylphenyl)-amine | HCID 23079293 | 99.8% |
Reaction Steps
The compound (521.6 mg) obtained in Example 39-1 was dissolved in methanol (15 ml) and added with hydrazine monohydrate (0.11 ml), followed by stirring at 60° C. for 1.5 hours. The reaction solution was added with a 1 mol/l sodium hydroxide aqueous solution and then subjected to extraction with chloroform. Subsequently, the organic layer was washed with saturated saline solution and then dried with anhydrous sodium sulfate. After the solvent had been distilled off, the subject compound (372 mg) was obtained as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07176227B2 |
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| Source dataset | uspto-grants-2007_02 |
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| ORD ID | ord-b21b5d423cef4c10a65af49d9fe7e2f3 |
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| Source note | uspto-grants-2007_02 |
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