反应详情

The compound (104.9 mg) obtained in Example 47-3 was dissolved in methanol (3.2 ml) and then added with 6-bromopyridine-2-aldehyde (55.8 mg) and sodium cyanoborohydride (31.4 mg). Then, the solution was adjusted to pH 5 with acetic acid and then stirred at room temperature for 14 hours. After completion of the reaction, a 1 mol/l sodium hydroxide aqueous solution was added to the reaction solution, followed by separation/extraction with chloroform. The organic layer was dried with anhydrous sodium sulfate and the solvent was then distilled off. The residue was purified through silica gel column chromatography (chloroform/ethyl acetate) and then treated with hydrochloric acid, thereby obtaining hydrochloride (91.9 mg) of the subject compound as a white solid.

1. customAfter completion of the reaction
2. extractionfollowed by separation/extraction with chloroform
3. dry with materialThe organic layer was dried with anhydrous sodium sulfate
4. distillationthe solvent was then distilled off
5. customThe residue was purified through silica gel column chromatography (chloroform/ethyl acetate)
6. additiontreated with hydrochloric acid