Acetic Acid → N-[4-[(dipropylamino)methyl]phenyl]-4-[[(1-methylimidazol-2-yl)methyl-(1H-1,2,4-triazol-3-ylmethyl)amino]methyl]benzamide

Participants

Reaction Steps

The compound (256.8 mg) obtained in Example 122-4 was dissolved in methanol (7.7 ml) and added with 1H-[1,2,4]-triazol-3-carboxaldehyde (115.0 mg) and sodium cyanoborohydride (74.4 mg). Then, the solution was adjusted to pH 5 with acetic acid and stirred at room temperature for 14 hours. The reaction solution was concentrated under reduced pressure. Subsequently, the residue was purified through silica gel column chromatography (chloroform/methanol) and treated with hydrochloric acid, thereby obtaining hydrochloride (337.9 mg) of the subject compound as a white solid.

Provenance & Evidence